User profiles for "author:K Pfeffer"

Karin Pfeffer

Verified email at uva.nl
Cited by 3811

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

T Hehlgans, K Pfeffer - Immunology, 2005 - Wiley Online Library
The members of the tumour necrosis factor (TNF)/tumour necrosis factor receptor (TNFR)
superfamily are critically involved in the maintenance of homeostasis of the immune system …

Biological functions of tumor necrosis factor cytokines and their receptors

K Pfeffer - Cytokine & growth factor reviews, 2003 - Elsevier
Tumor necrosis factor (TNF; formerly known as TNFα) and lymphotoxin (LT) α, originally
characterized by their ability to induce tumor cell apoptosis and cachexia, are now …

[HTML][HTML] Slums from space—15 years of slum mapping using remote sensing

M Kuffer, K Pfeffer, R Sliuzas - Remote Sensing, 2016 - mdpi.com
The body of scientific literature on slum mapping employing remote sensing methods has
increased since the availability of more very-high-resolution (VHR) sensors. This improves …

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

K Pfeffer, T Matsuyama, TM Kündig, A Wakeham… - Cell, 1993 - cell.com
The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct
cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we …

Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice

JAL Flynn, MM Goldstein, J Chan, KJ Triebold, K Pfeffer… - Immunity, 1995 - cell.com
Understanding the immunological mechanismsof protection and pathogenesis in
tuberculosis remains problematic. We have examined the extent to which tumor necrosis …

Differential T cell costimulatory requirements in CD28-deficient mice

A Shahinian, K Pfeffer, KP Lee, TM Kündig, K Kishihara… - Science, 1993 - science.org
T cell receptor stimulation without costimulation is insufficient for the induction of an optimal
immune response. It is thought that engagement of the CD28 molecule with its ligand B7 …

[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

…, U Ohler, S Ossowski, J Overmann, S Peter, K Pfeffer… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

…, P Deroos, H Liu, JR Cross, K Pfeffer… - Nature, 2013 - nature.com
Intestinal microbes provide multicellular hosts with nutrients and confer resistance to
infection. The delicate balance between pro-and anti-inflammatory mechanisms, essential …

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

…, JM Garcia-Verdugo, JR Fike, HO Lee, K Pfeffer… - Nature, 2003 - nature.com
Recent studies have suggested that bone marrow cells possess a broad differentiation
potential, being able to form new liver cells, cardiomyocytes and neurons,. Several groups …

B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

…, RC Lindsley, K Hildner, S Scheu, K Pfeffer… - Nature …, 2005 - nature.com
B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and T cells.
Previously, indirect observations suggested that B7x was a ligand for BTLA. Here we show …