Hormone therapy is still used by millions of women for menopausal symptoms. Concerns
regarding hormone therapy and breast cancer were initially based on case reports and …

ContextDespite decades of accumulated observational evidence, the balance of risks and
benefits for hormone use in healthy postmenopausal women remains uncertain. ObjectiveTo …

Background The efficacy of calcium with vitamin D supplementation for preventing hip and
other fractures in healthy postmenopausal women remains equivocal. Methods We recruited …

ContextMultiple epidemiologic studies and some trials have linked diet with cardiovascular
disease (CVD) prevention, but long-term intervention data are needed. ObjectiveTo test the …

Background Fine particulate air pollution has been linked to cardiovascular disease, but
previous studies have assessed only mortality and differences in exposure between cities …

Background Higher intake of calcium and vitamin D has been associated with a reduced risk
of colorectal cancer in epidemiologic studies and polyp recurrence in polyp-prevention trials …

ContextThe hypothesis that a low-fat dietary pattern can reduce breast cancer risk has
existed for decades but has never been tested in a controlled intervention trial. ObjectiveTo …

Obesity has been consistently associated with an increased risk of postmenopausal breast
cancer in population-based studies. Conversely, obesity in such studies has been inversely …

ContextThe Women's Health Initiative Estrogen-Aone trial comparing conjugated equine
estrogens (CEE) with placebo was stopped early because of an increased stroke incidence …

Context In the Women's Health Initiative randomized, placebo-controlled trial of estrogen
plus progestin, after a mean intervention time of 5.6 (SD, 1.3) years (range, 3.7-8.6 years) …