Number of episodes of injury and personal characteristics of 412 individuals living in a state-operated ICF/MR during 1994 were examined. Results indicated that 16% of the facility population experienced 67% of the injuries. Discriminant functions were created using chlorpromazine equivalent level combined with maladaptive behavior, medical, and adaptive behavior factors to classify individuals into high and low injury groups. Individuals taking antipsychotics, having higher maladaptive behavior scores, and having relatively higher levels of adaptive behavior were most likely to be in the high injury group. We concluded that episodes of injury were not evenly distributed across the individuals and certain personal characteristics discriminated high from low risk groups.