This mixed-method study examined the facilitators and barriers discussed by 166 informants interviewed from 78 innovative mental health projects. Facilitator and barrier coding reflected two dimensions: the topic of the comment (e.g., funding); and the time phase of the issue's influence (e.g., pre-decision). Proportions of facilitators to the sum of facilitator and barrier comments made by project informants were calculated. Overall, facilitator proportions were higher for projects that proceeded with implementation than those that did not adopt the practice. In addition, facilitator proportions were generally highest at pre-decision and lowest at full implementation for implementing projects.