The Manitoba Centre for Health Policy and Evaluation (MCHPE) developed POPULIS, a population-based health information system, as a vehicle for changing the way we think about the role of health care as a determinant of health. Serving as a bridge between analysts who produce research and politicians and policymakers who use it, MCHPE has developed a research infrastructure that can transform routinely collected administrative data into policy-relevant information. This paper provides a description of Manitoba and its health care system, as well as how MCHPE was started and how it functions. It describes how we at the Centre work with various databases, from the acquisition process through developing concepts and capabilities to the final validity and sensitivity testing of results. We detail the role of a population-based conceptual framework in challenging those who suggest more spending on medical care is self-evidently desirable.