Table 1

Sample characteristics of women, aged 40–64, all mental disorders excluded

Characteristic	SSRI, N=137 031 N=137 031	Per cent	H2A/PPIs, N=236 294 N=236 294	Per cent	H2A/PPIs weighted to SSRI (%)
Age at index date
40–49	64 227	46.7	91 422	38.6	46.8
50–59	54 297	39.7	101 360	42.9	39.5
60–64	18 507	13.6	43 512	18.4	13.7
ACE inhibitors	11 899	8.7	24 187	10.2	8.8
Antipsychotics	2372	1.7	4661	2.9	1.8
Angiotensin receptor blockers	5116	3.7	11 365	4.8	3.8
Cardiac arrhythmias	4775	3.5	11 472	4.9	3.5
Rheumatoid arthritis	2169	1.6	5517	2.3	1.6
Barbiturate	106	0.1	196	0.1	0.1
β Blockers	14 609	10.7	29 363	12.4	10.8
Benzodiazepine	25 348	18.5	21 372	9.1	18.6
History of falls, syncope or gait abnormality	6623	4.8	14 625	6.2	5.0
Bone mineral density scan	10 864	7.9	23 834	10.1	8.0
Cataracts	4148	3.0	10 086	4.3	3.1
Calcium channel blockers	8468	6.2	19 704	8.3	6.2
Myocardial infarction	719	0.5	2004	0.8	0.5
Paraplegia and hemiplegia	193	0.1	319	0.1	0.1
Moderate or severe liver disease	109	0.1	387	0.2	0.1
AIDS/HIV	110	0.1	288	0.1	0.1
Peripheral vascular disease	1930	1.4	5027	2.1	1.4
Peptic ulcer disease	613	0.4	6234	2.6	0.5
Congestive heart failure	1364	1.0	3786	1.6	1.0
Asthma/COPD	12 514	9.1	29 499	12.5	9.3
Cox-2 inhibitors	7078	5.2	13 348	5.6	5.3
Crohn's disease/gastroenteritis	3274	2.4	9435	4.0	2.4
Diabetes	9806	7.2	21 363	9.0	7.3
Glucocorticosteroids	16 743	12.2	42 231	17.9	12.5
Hip fracture	94	0.1	248	0.1	0.1
Hormone replacement therapy	23 500	17.1	36 663	15.5	17.4
Humerus fracture	208	0.2	381	0.2	0.2
Hyperparathyroidism	304	0.2	776	0.3	0.2
Hyperthyroidism	1750	1.3	3536	1.5	1.3
Irritable bowel syndrome	2867	2.1	4403	1.9	2.2
Kyphosis	670	0.5	1420	0.6	0.5
Liver disease	3328	2.4	8975	3.8	2.5
Malignant neoplasm cancer	8251	6.0	17 071	7.2	6.1
Other NSAIDs	27 493	20.1	60 450	25.6	20.3
Number of drugs
1 (SSRI/ulcer drug only)	11 811	8.6	13 142	5.6	8.5
2–3	28 683	20.9	40 366	17.1	20.6
4–5	27 022	19.7	46 020	19.5	19.5
6–9	37 066	27.0	73 018	30.9	27.0
10+	32 449	23.7	63 748	27.0	24.4
Number of hospitalisations, 1+	9609	7.0	27 101	11.5	7.2
Number of outpatient visits
<5	36 219	26.4	37 887	16.0	26.1
5–9	33 513	24.5	50 939	21.6	24.3
10–19	37 209	27.2	77 341	32.7	27.2
20–39	22 108	16.1	52 677	22.3	16.4
40+	7982	5.8	17 450	7.4	6.1
Overweight or obese	4680	3.4	13 240	5.6	3.5
Opioid use	41 066	30.0	79 917	33.8	30.7
Osteoporosis	4663	3.4	11 529	4.9	3.4
Other fracture	2952	2.2	5668	2.4	2.2
Parkinson's disease	1290	0.9	1692	0.7	1.0
Perimenopausal symptoms	13 261	9.7	17 202	7.3	9.7
Radius/ulna fracture	508	0.4	865	0.4	0.4
Renal disease	452	0.3	1373	0.6	0.3
Seizure	545	0.4	934	0.4	0.4
Ischaemic stroke	1010	0.7	1726	0.7	0.8
Thiazides	8355	6.1	17 381	7.4	6.1
Thyroid medication	17 230	12.6	27 909	11.8	12.7
Urinary incontinence	1833	1.3	3484	1.5	1.4
Vertebral fracture	299	0.2	639	0.3	0.2

New users of SSRIs or H2A/PPIs, unweighted and weighted cohorts.
COPD, chronic obstructive pulmonary disease; H2As, H2 antagonists; NSAIDs, non-steroidal anti-inflammatory drugs; PPI, proton-pump inhibitor; SSRI, selective serotonin reuptake inhibitor.