Table 2

SSRI versus H2A/PPI fracture event rates, stratified by follow-up time

Period	Drug	Number contributing	Number of events	Total person time (years)	Rate per 1000 pr-years	95% CI
Panel A†
0–180 days	SSRI	110 957	72	39 511.81	1.8	1.4 to 2.3
	H2A/PPI	112 660	39	35 009.82	1.1	0.9 to 1.4
181–360 days	SSRI	45 823	40	16 201.11	2.5	1.8 to 3.4
	H2A/PPI	27 325	10	9008.76	1.1	0.7 to 1.6
0–1 year	SSRI	110 957	112	55 712.93	2.0	1.7 to 2.4
	H2A/PPI	112 660	49	44 018.58	1.1	0.9 to 1.4
1–2 years	SSRI	23 423	37	13 812.44	2.7	1.9 to 3.7
	H2A/PPI	123 712	12	7268.16	1.7	0.9 to 3.0
2–3 years	SSRI	7925	10	4929.88	2.0	1.1 to 3.8
	H2A/PPI	4189	4	2696.20	1.3	0.6 to 2.8
3–4 years	SSRI	3153	6	2184.02	2.8	1.2 to 6.1
	H2A/PPI	1778	3	1227.03	2.3	0.9 to 5.5
4–5 years	SSRI	1385	0	840.60	0	N/A
	H2A/PPI	798	1	483.06	1.8	0.3 to 12.7
0–5 years	SSRI	110 957	165	77 479.87	2.1	1.8 to 2.5
	H2A/PPI	112 660	68	55 693.03	1.2	1.0 to 1.5
Panel B‡
0–180 days	SSRI	110 957	81	48 805.32	1.7	1.3 to 2.1
	H2A/PPI	112 660	61	49 906.19	1.2	1.0 to 1.5
181–360 days	SSRI	88 126	61	38 663.23	1.6	1.2 to 2.0
	H2A/PPI	90 582	38	39 868.69	1.0	0.7 to 1.2
0–1 year	SSRI	110 957	142	87 468.54	1.6	1.4 to 1.9
	H2A/PPI	112 660	99	89 774.88	1.1	0.9 to 1.3
1–2 years	SSRI	68 960	95	52 368.98	1.8	1.5 to 2.2
	H2A/PPI	71 520	73	55 187.09	1.3	1.1 to 1.6
2–3 years	SSRI	39 704	50	29 756.54	1.7	1.3 to 2.2
	H2A/PPI	42 453	34	32 475.37	1.1	0.8 to 1.4
3–4 years	SSRI	23 135	28	17 633.26	1.6	1.1 to 2.3
	H2A/PPI	25 375	27	19 408.85	1.4	1.0 to 1.9
4–5 years	SSRI	12 996	15	8972.10	1.7	1.0 to 2.8
	H2A/PPI	14 577	23	10 271.05	2.3	1.5 to 3.4
0–5 years	SSRI	110 957	330	196 199.43	1.7	1.5 to 1.9
	H2A/PPI	112 660	257	207 117.24	1.2	1.1 to 1.4

Number contributing and number of events rounded to integers.
†Women, aged 40–64, as-treated analysis, 180-day lag, 180-day induction period.
‡Women, aged 40–64, first-treatment-carried-forward analysis, 180-day lag period.
H2A, H2 antagonist; PPI, proton-pump inhibitor; SSRI, selective serotonin reuptake inhibitor.