RT Journal Article SR Electronic T1 Methodological considerations in MVC epidemiological research JF Injury Prevention JO Inj Prev FD BMJ Publishing Group Ltd SP injuryprev-2020-043987 DO 10.1136/injuryprev-2020-043987 A1 Liraz Fridman A1 Linda Rothman A1 Andrew William Howard A1 Brent E Hagel A1 Colin Macarthur YR 2020 UL http://injuryprevention.bmj.com/content/early/2020/11/16/injuryprev-2020-043987.abstract AB Background The global burden of MVC injuries and deaths among vulnerable road users, has led to the implementation of prevention programmes and policies at the local and national level. MVC epidemiological research is key to quantifying MVC burden, identifying risk factors and evaluating interventions. There are, however, several methodological considerations in MVC epidemiological research.Methods This manuscript collates and describes methodological considerations in MVC epidemiological research, using examples drawn from published studies, with a focus on the vulnerable road user population of children and adolescents.Results Methodological considerations in MVC epidemiological research include the availability and quality of data to measure counts and calculate event rates and challenges in evaluation related to study design, measurement and statistical analysis. Recommendations include innovative data collection (eg, naturalistic design, stepped-wedge clinical trials), combining data sources for a more comprehensive representation of collision events, and the use of machine learning/artificial intelligence for large data sets.Conclusions MVC epidemiological research can be challenging at all levels: data capture and quality, study design, measurement and analysis. Addressing these challenges using innovative data collection and analysis methods is required.