Background The disproportionate burden of injuries in low-resource settings is a global health challenge demanding context-specific and locally driven solutions. Bangladesh, more specifically, Centre for Injury Prevention and Research, Bangladesh (CIPRB) recognized the urgency of tackling injuries as a major public health problem in Bangladesh starting in 2005. While early efforts relied on conventional research methods, CIPRB’s dedication led them to identify the need for culturally sensitive and socio-economically relevant approaches to effectively address injuries within constrained resource settings.

Objectives The main objective of this research is to analyze CIPRB’s two decades of experience to develop a scalable model for building thriving injury research ecosystems in low-resource settings.

Policy Analysis Performed a comprehensive analysis of all research projects conducted by the CIPRB throughout its tenure. This analysis utilized a structured checklist to evaluate research methodologies, publication outputs, and contributions to national and global injury prevention initiatives.

Paradigm shift

• Crafting research tools and methods that fit the realities of low-resource settings, leveraging readily available data sources and culturally appropriate techniques to ensure insightful and impactful studies.

• Shifting the center: From researcher-driven agendas to co-designed research plans reflecting community priorities and expertise. Building trust and collaboration, integrating traditional knowledge and practices with scientific expertise to enhance engagement and relevance.

Bridging knowledge gap:

• Building research resilience: Targeted training ensures local researchers have the skills and knowledge to gather, analyze, and share critical data, empowering them to address local challenges with impactful research.

• Building Bridges, Breaking Barriers: Fostering collaboration, knowledge exchange, and policy advocacy among researchers in low-resource settings. Cultivating partnerships that provide mentorship, resources, and funding while upholding local priorities and intellectual ownership.

Conclusions Shifting the paradigm in injury research for low-resource settings requires prioritizing research methods that resonate with cultures, adapt to socioeconomic realities, and actively engage communities. This is the key to transformative impact.