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Prevalence, recovery patterns and predictors of quality of life and costs after non-fatal injury: the Brabant Injury Outcome Surveillance (BIOS) study
  1. M A C de Jongh1,2,
  2. N Kruithof1,
  3. T Gosens1,3,
  4. C L P van de Ree1,
  5. L de Munter1,
  6. L Brouwers2,
  7. S Polinder4,
  8. K W W Lansink1,2,5,
  9. BIOS-group
    1. 1Department Trauma TopCare, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands
    2. 2Network Emergency Care Brabant, Brabant Trauma Registry, The Netherlands
    3. 3Department of Orthopaedics, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands
    4. 4Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    5. 5Department of Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands
    1. Correspondence to Dr M A C de Jongh, Department of Trauma TopCare, Elisabeth-TweeSteden Hospital, Postbus 90151, Tilburg 5000LC, The Netherlands; m.dejongh{at}


    Introduction Trauma is a major public health problem worldwide that leads to high medical and societal costs. Overall, improved understanding of the full spectrum of the societal impact and burden of injury is needed. The main purpose of the Brabant Injury Outcome Surveillance (BIOS) study is to provide insight into prevalence, predictors and recovery patterns of short-term and long-term health-related quality of life (HRQoL) and costs after injury.

    Materials and methods This is a prospective, observational, follow-up cohort study in which HRQoL, psychological, social and functional outcome, and costs after trauma will be assessed during 24 months follow-up within injured patients admitted in 1 of 10 hospitals in the county Noord-Brabant, the Netherlands. Data will be collected by self-reported questionnaires at 1 week (including preinjury assessment), and 1, 3, 6, 12 and 24 months after injury. If patients are not capable of filling out the questionnaires, proxies will be asked to participate. Also, information about mechanism and severity of injury, comorbidity and indirect and direct costs will be collected. Mixed models will be used to examine the course of HRQoL, functional and psychological outcome, costs over time and between different groups, and to identify predictors for poor or good outcome.

    Relevance This study should make a substantial contribution to the international collaborative effort to assess the societal impact and burden of injuries more accurately. The BIOS results will also be used to develop an outcome prediction model for outcome evaluation including, besides the classic fatal, non-fatal outcome.

    Trial registration number NCT02508675.

    • Outcome of Injury

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    • Collaborators Members of the BIOS group: P V van Eerten, F C van Eijck, H J A A van Geffen, W A J J M Haagh, L M S J Poelhekke, J B Sintenie, C T Stevens, A H van der Veen, C H van der Vlies and D I Vos.

    • Contributors All authors contributed to the paper.

    • Funding ZonMw (80-84200-98-14255).

    • Competing interests None declared.

    • Ethics approval Medical Ethics Committee Brabant (project number NL50258.028.14).

    • Provenance and peer review Not commissioned; internally peer reviewed.