User profiles for "author:Yi-han Sheu"

Yi-han Sheu

Harvard University, Massachusetts General Hospital, Broad Institute
Verified email at mail.harvard.edu
Cited by 298

[HTML][HTML] Illuminating the black box: interpreting deep neural network models for psychiatric research

Y Sheu - Frontiers in Psychiatry, 2020 - frontiersin.org
Psychiatric research is often confronted with complex abstractions and dynamics that are not
readily accessible or well-defined to our perception and measurements, making data-driven …

[HTML][HTML] Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

ML Charpignon, B Vakulenko-Lagun, B Zheng… - Nature …, 2022 - nature.com
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …

[HTML][HTML] AI-assisted prediction of differential response to antidepressant classes using electronic health records

Y Sheu, C Magdamo, M Miller, S Das, D Blacker… - NPJ Digital …, 2023 - nature.com
Antidepressant selection is largely a trial-and-error process. We used electronic health
record (EHR) data and artificial intelligence (AI) to predict response to four antidepressants …

Large Language Models in Mental Health Care: a Scoping Review

Y Hua, F Liu, K Yang, Z Li, Y Sheu, P Zhou… - arXiv preprint arXiv …, 2024 - arxiv.org
Objective: The growing use of large language models (LLMs) stimulates a need for a
comprehensive review of their applications and outcomes in mental health care contexts …

Firearm access and adolescent suicide risk: toward a clearer understanding of effect size

SA Swanson, M Eyllon, YH Sheu… - Injury …, 2021 - injuryprevention.bmj.com
Background Strong and consistent associations between access to firearms and suicide
have been found in ecologic and individual-level observational studies. For adolescents, a …

Impact of selection bias on polygenic risk score estimates in healthcare settings

YH Lee, T Thaweethai, YH Sheu, YCA Feng… - Psychological …, 2023 - cambridge.org
BackgroundHospital-based biobanks are being increasingly considered as a resource for
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …

Serotonin–norepinephrine reuptake inhibitor and selective serotonin reuptake inhibitor use and risk of fractures: a new-user cohort study among US adults aged 50 …

A Lanteigne, Y Sheu, T Stürmer, V Pate, D Azrael… - CNS drugs, 2015 - Springer
Background Antidepressants may increase the risk of fractures by disrupting sensory-motor
function, thereby increasing the risk of falls, and by decreasing bone mineral density and …

SSRI use and risk of fractures among perimenopausal women without mental disorders

Y Sheu, A Lanteigne, T Stürmer, V Pate… - Injury …, 2015 - injuryprevention.bmj.com
Background Selective serotonin reuptake inhibitors (SSRIs) were recently approved by the
FDA to treat vasomotor symptoms associated with menopause. No prior study has directly …

[HTML][HTML] An efficient landmark model for prediction of suicide attempts in multiple clinical settings

YH Sheu, J Sun, H Lee, VM Castro, Y Barak-Corren… - Psychiatry …, 2023 - Elsevier
Growing evidence has shown that applying machine learning models to large clinical data
sources may exceed clinician performance in suicide risk stratification. However, many …

[HTML][HTML] Dosage and duration of antipsychotic treatment in demented outpatients with agitation or psychosis

YT Lin, TJ Hwang, JC Shan, HL Chiang… - Journal of the Formosan …, 2015 - Elsevier
Background/Purpose The USA Food and Drug Administration (FDA) issued warnings
regarding the use of antipsychotics in patients with dementia in 2003 and 2005. We aimed to …