User profiles for "author:Yi-han Sheu"
Yi-han SheuHarvard University, Massachusetts General Hospital, Broad Institute Verified email at mail.harvard.edu Cited by 298 |
[HTML][HTML] Illuminating the black box: interpreting deep neural network models for psychiatric research
Y Sheu - Frontiers in Psychiatry, 2020 - frontiersin.org
Psychiatric research is often confronted with complex abstractions and dynamics that are not
readily accessible or well-defined to our perception and measurements, making data-driven …
readily accessible or well-defined to our perception and measurements, making data-driven …
[HTML][HTML] Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia
Metformin, a diabetes drug with anti-aging cellular responses, has complex actions that may
alter dementia onset. Mixed results are emerging from prior observational studies. To …
alter dementia onset. Mixed results are emerging from prior observational studies. To …
[HTML][HTML] AI-assisted prediction of differential response to antidepressant classes using electronic health records
Antidepressant selection is largely a trial-and-error process. We used electronic health
record (EHR) data and artificial intelligence (AI) to predict response to four antidepressants …
record (EHR) data and artificial intelligence (AI) to predict response to four antidepressants …
Large Language Models in Mental Health Care: a Scoping Review
Objective: The growing use of large language models (LLMs) stimulates a need for a
comprehensive review of their applications and outcomes in mental health care contexts …
comprehensive review of their applications and outcomes in mental health care contexts …
Firearm access and adolescent suicide risk: toward a clearer understanding of effect size
SA Swanson, M Eyllon, YH Sheu… - Injury …, 2021 - injuryprevention.bmj.com
Background Strong and consistent associations between access to firearms and suicide
have been found in ecologic and individual-level observational studies. For adolescents, a …
have been found in ecologic and individual-level observational studies. For adolescents, a …
Impact of selection bias on polygenic risk score estimates in healthcare settings
BackgroundHospital-based biobanks are being increasingly considered as a resource for
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …
Serotonin–norepinephrine reuptake inhibitor and selective serotonin reuptake inhibitor use and risk of fractures: a new-user cohort study among US adults aged 50 …
Background Antidepressants may increase the risk of fractures by disrupting sensory-motor
function, thereby increasing the risk of falls, and by decreasing bone mineral density and …
function, thereby increasing the risk of falls, and by decreasing bone mineral density and …
SSRI use and risk of fractures among perimenopausal women without mental disorders
Background Selective serotonin reuptake inhibitors (SSRIs) were recently approved by the
FDA to treat vasomotor symptoms associated with menopause. No prior study has directly …
FDA to treat vasomotor symptoms associated with menopause. No prior study has directly …
[HTML][HTML] An efficient landmark model for prediction of suicide attempts in multiple clinical settings
Growing evidence has shown that applying machine learning models to large clinical data
sources may exceed clinician performance in suicide risk stratification. However, many …
sources may exceed clinician performance in suicide risk stratification. However, many …
[HTML][HTML] Dosage and duration of antipsychotic treatment in demented outpatients with agitation or psychosis
YT Lin, TJ Hwang, JC Shan, HL Chiang… - Journal of the Formosan …, 2015 - Elsevier
Background/Purpose The USA Food and Drug Administration (FDA) issued warnings
regarding the use of antipsychotics in patients with dementia in 2003 and 2005. We aimed to …
regarding the use of antipsychotics in patients with dementia in 2003 and 2005. We aimed to …