Wiring up the nervous system depends on the precise guidance of axonal growth cones to
their targets. A key mechanism underlying this guidance is chemotaxis, whereby growth …

Background. Algorithms for converting descriptive measures of health status into quality-
adjusted life year (QALY)—weights are now widely available, and their application in …

Which gates are universal for quantum computation? Although it is well known that certain
gates on two-level quantum systems (qubits), such as the controlled-not, are universal when …

How useful is a quantum dynamical operation for quantum information processing?
Motivated by this question, we investigate several strength measures quantifying the …

Background Obesity hypoventilation syndrome (OHS) is the most common indication for
home ventilation, although the optimal therapy remains unclear, particularly for severe …

Objectives: Debate regarding factors associated with persistent symptoms following mild
traumatic brain injury continues. Nested within a trial aiming to change practice in …

Introduction This cluster randomised trial evaluated an intervention to decrease x-ray
referrals and increase giving advice to stay active for people with acute low back pain (LBP) …

Background There is an increasing body of published cost-utility analyses of health
interventions which we sought to draw together to inform research and policy. Methods To …

Axon guidance by molecular gradients plays a crucial role in wiring up the nervous system.
However, the mechanisms axons use to detect gradients are largely unknown. We first …

Purpose Health-related quality of life (HRQOL) can be significantly impaired by the presence
of chronic conditions such as cardiovascular disease (CVD) and major depressive disorder …