Background Concerns regarding the safety of transfused blood have led to the development
of a range of interventions to minimise blood loss during major surgery. Anti‐fibrinolytic …

Background A number of approaches have been used to grade levels of evidence and the
strength of recommendations. The use of many different approaches detracts from one of the …

ContextEvidence that rofecoxib increases the risk of myocardial infarction has led to scrutiny
of other nonsteroidal anti-inflammatory drugs (NSAIDs). Regulatory agencies have provided …

The number of published systematic reviews of studies of healthcare interventions has
increased rapidly and these are used extensively for clinical and policy decisions …

Non-randomised studies of the effects of interventions are critical to many areas of
healthcare evaluation, but their results may be biased. It is therefore important to understand …

OBJECTIVE: Our purpose was to measure the agreement, reliability, construct validity, and
feasibility of a measurement tool to assess systematic reviews (AMSTAR). STUDY DESIGN …

Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

Background Chronic immune thrombocytopenic purpura (ITP) is characterised by
accelerated platelet destruction and decreased platelet production. Short-term …

Purpose This study compared denosumab, a fully human monoclonal anti-receptor activator
of nuclear factor kappa-B ligand antibody, with zoledronic acid (ZA) for delaying or …

A lot of money can be made from healthy people who believe they are sick. Pharmaceutical
companies sponsor diseases and promote them to prescribers and consumers. Ray …