The aim of the study was to evaluate associations of some lifestyle factors with injuries among schoolchildren. Analysis was performed using data from the survey conducted in 2002 according to the methods of World Health Organization Cross-National Study on Health Behavior in School-Aged Children (HBSC). Using stratified random sampling, the representative sample of 5645 schoolchildren aged 11, 13, and 15 years from 104 schools of Lithuania was drawn and surveyed. Associations between potential risk factors and injuries among schoolchildren were evaluated calculating odds ratio and its 95% confidence intervals. For the evaluation of the impact of explanatory variables on analyzed event, logistic regression analysis was performed. Behavioral, psychological, and social integration factors were associated with the risk to sustain injuries among school-aged children. The impact of these factors varied within subgroups of schoolchildren by grade and sex. The most significant factors were: risk-taking behavior (smoking, alcohol and drug consumption, premature sexual activity), frequent participation in sport activities, involvement in physical fight, longer time spent away from home with friends, experienced bullying, poor self-assessed health and academic achievement, unhappiness, feeling unsafe at school, and high suicidal risk. Analysis failed to identify an expected association between lower socio-economic status and risk for injury. Integrated approach to injury etiology is essential in planning injury prevention and safety promotion activities among schoolchildren, paying particular attention to lifestyle factors, which can have the potential influence on risk to sustain injuries.